Dr David McGrath

Spine Physician

MB BS (Hons) FAFOM, RACP, FAFMM
Master of Pain Medicine

Vitamin Interactions A, D, E, K

Toxicity of high levels of vitamins depends on its balance with other vitamins.
This table illustrates, some of the interaction between vit A and Vit D

1. Adapted from "Vitamin A on Trial" by Chris Masterjohn

VitaminsEffects	Reported Diseases	Biochemical Observations
Normal D Normal A	NIL	NIL
Low D Normal A	Rickets Osteomalacea Malnourishment Eye disorders	Low 25(OH)D3 levels
High D Normal A	Kidney Disease with Mineral Deposition	High 25(OH)D3 compared to Retinol
Normal D Low A	Poor Night Vision Dry Eyes Acne Dry Skin Poor Immune System Altered Bone Growth	Low Retinol Levels
Normal D High A	Retarded Growth Lameness Osteoporosis Fractures Poor growth Plates	High Retinol compared to 25(OH)D3
Low D Low A	Retarded Growth Lameness	Low D3 and Retinol
High D High A	NIL	High Retinol and D3 levels

1.Estimated ideal ratio serum Retinol micromoles/ serum 25(OH)D3 ng/ml= (2/19) note different dimensions
Higher levels of both good
2. High levels of Vit A has correlated with lower levels of Vit E,K,D
2. Toxicity of vitamins depends on its balance with other vitamins